A, Jegier P, Wolf B. H, Sudhof T. Molecular determinants of regulated exocytosis. D, Mossner R, Neher E. Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules.
Impairment of glycerol phosphate shuttle in islets from rats with diabetes induced by neonatal streptozocin. Impairment of insulin secretion in man by nifedipine. Phosphorylation of SNAP on serine is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion.
K, Hinkle P. B, Lang J. N, Milner R. Cations and the secretion of insulin from rabbit pancreas in vitro. A, Kane C, James R. F, London N. J, Dunne M.
Modulation of three types of potassium selective channels by NAD and other pyridine nucleotides in human pancreatic beta-cells. J, Capito K, Thams P. Triggering and amplifying pathways of regulation of insulin secretion by glucose. I, Donoso P. B, Spat A, Enyedi P. Voltage dependent calcium channels in adrenal glomerulosa cells and in insulin producing cells.
Cell Calcium. M, Wollheim C. B, Berggren P. O, Gromada J. FEBS Lett. G, Lazdunski M. EMBO J. N, Collinson L. M, Hopkins C. R, Strom M, Barral D. C, Bossi G, Griffiths G.
M, Seabra M. The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Myosin light-chain phosphorylation controls insulin secretion at a proximal step in the secretory cascade. R, Wollheim C. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. A, Galvanovskis J, Renstrom E. Temperature-sensitive random insulin granule diffusion is a prerequisite for recruiting granules for release.
Mammalian glucokinase and its gene. B, Reuveny E, Lotan I. A, Monck J. R, Weiss J. N, Ribalet B. Effects of nifedipine on insulin secretion and glucose metabolism in rats and in hypertensive type 2 non-insulin dependent diabetics. I, Snyder S. H, Linden D. Reduced nicotinamide adenine dinucleotide-selective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium.
G, Caloca M. L, Reilly M, Wang H. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. H, Rajan A. S, Boyd A. P, Sutton R, Ashcroft F. D, Maechler P, Wollheim C. A, Satin L. The in vitro inhibition of insulin secretion by diphenylhydantoin. Enzymes in pancreatic islets that use NADP H as a cofactor including evidence for a plasma membrane aldehyde reductase. Cell Biochem.
E, Finke E. H, Codilla R. Cinemicrographic studies on beta granule movement in monolayer culture of islet cells. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. J, Herchuelz A. S, Hur E. M, Suh B. C, Kim M.
H, Koh D. S, Rhee I. J, Ha H, Kim K. Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. R, Grodsky G. M, Hagura R, Smith D. Comparison of the inhibitory effects of diphenylhydantoin and diazoxide upon insulin secretion from the isolated perfused pancreas. Class A calcium channel variants in pancreatic islets and their role in insulin secretion. L, Pfeiffer D. C, Jensen M. V, Kamzolova S, Newgard C. B, Sherry A. Evidence for the malate aspartate shuttle in pancreatic islets.
Estimates of glycolysis, pyruvate de carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets. E, Wheeler M. J, Ammon H. P, Patel T, Steinke J. Failure of 6-aminonicotinamide to inhibit the potentiating effect of leucine and arginine on glucose-induced insulin release in vitro. E, Ha X. F, Wang J, Smukler S.
R, Sun A. M, Gaisano H. Y, Salapatek A. M, Backx P. H, Wheeler M. E, et al. Inhibition of Kv2. E, Salapatek A. M, Wheeler M. Temperature and redox state dependence of native Kv2. J, Fahien L.
A, Brown L. J, Hasan N. M, Buss J. D, Kendrick M. Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. D, Pozzan T, Wollheim C. A, Wollheim C. Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells.
Dynamics of insulin release and microtubular—microfilamentous system. A model for the phasic release of insulin. Insulin release: the fuel hypothesis. E, Nichols C. G, Light P. Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues.
Banting Lecture A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. K, Sakamoto Y. Electrical characteristics of pancreatic islet cells. P, Schmelz H. Membrane potential of beta-cells in pancreatic islets. P, Henquin J. C, Preissler M. Potassium dependence of the membrane potential of pancreatic B-cells.
Fusion has found its calcium sensor. Cell Biol. F, Leibiger I. O, Bertorello A. Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis. J, Worley J. F, Spencer B, Johnson J. H, Dukes I. Evidence for privileged signaling by glycolysis. D, Thebaud B, Weir E. K, Archer S. V, Proks P, Ashcroft F. Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
D, Hales C. Cations and the secretion of insulin. A, McGarry J. K, Thurmond D. Circ Res. Balaban RS. Modeling mitochondrial function.
Am J Physiol Cell Physiol. Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation. J Physiol. Strong inference for systems biology. Wiederkehr A, Wollheim CB. Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.
Cell Calcium. Affourtit C, Brand MD. Biochem J. Am J Physiol Endocrinol Metab. Impaired metabolism-secretion coupling in pancreatic beta-cells: role of determinants of mitochondrial ATP production.
Diabetes Res Clin Pract. Mulder H, Ling C. Mitochondrial dysfunction in pancreatic beta-cells in type 2 diabetes. Mol Cell Endocrinol. Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis. Curr Diabetes Rev. Glucose sensing in the pancreatic beta cell: a computational systems analysis.
Theor Biol Med Model. Dzbek J, Korzeniewski B. Control over the contribution of the mitochondrial membrane potential DeltaPsi and proton gradient DeltapH to the protonmotive force Deltap. In silico studies. J Biol Chem. Nichols D. Biochim Biophys Acta. Amo T, Brand MD. Were inefficient mitochondrial haplogroups selected during migrations of modern humans?
A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Kadenbach B. Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion.
Chance B, Williams GR. The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem. Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets. Energy metabolism in islets of Langerhans.
Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential.
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Brand MD. The efficiency and plasticity of mitochondrial energy transduction. Biochem Soc Trans. On the role of uncoupling protein-2 in pancreatic beta cells. Mitochondrial uncoupling protein 2 in pancreatic beta-cells. Diabetes Obes Metab. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. A simplified nomenclature.
Homeodomain proteins. Annu Rev Biochem. Trainor PA, Krumlauf R. Hox genes, neural crest cells and branchial arch patterning. Curr Opin Cell Biol. IPF1, a homeodomain-containing transactivator of the insulin gene.
Embo J. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol. IDX a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.
Genes Dev. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.
Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Homeosis and intestinal tumours in Cdx2 mutant mice. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Wang M, Drucker DJ. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription.
Activation of amylin gene transcription by LIM domain homeobox gene isl Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. The RIPE3b1 activator of the insulin gene is composed of a protein s of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.
Molecular characterization of the rat insulin enhancer-binding complex 3b2. Cloning of a binding factor with putative helicase motifs. MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.
MafA is a key regulator of glucose-stimulated insulin secretion. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Sosa-Pineda B. The gene Pax4 is an essential regulator of pancreatic beta-cell development.
Mol Cells. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes. Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence. Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.
The expression of three members of the achaete-scute gene complex correlates with neuroblast segregation in Drosophila. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer.
A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets. Positive and negative regulation of the human insulin gene by multiple trans-acting factors. Le Lay J, Stein R. Involvement of PDX-1 in activation of human insulin gene transcription. J Endocrinol. Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.
Transcription factors coupled to the cAMP-signalling pathway. Biochim Biophys Acta. Nucleic Acids Res. Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter. Suckale J, Solimena M.
Pancreas islets in metabolic signaling--focus on the beta-cell. Front Biosci. Glucose activates a protein phosphatasemediated signaling pathway to enhance overall translation in pancreatic beta-cells. Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs.
Ortsater H, Sjoholm A. A busy cell--endoplasmic reticulum stress in the pancreatic beta-cell. Mol Cell Endocrinol.
Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells. Eur J Cell Biol. Nat Cell Biol. Itoh N, Okamoto H.
Translational control of proinsulin synthesis by glucose. Insulin biosynthesis. On the mechanism of glucose stimulation. Spellman R, Smith CW. Novel modes of splicing repression by PTB. Trends Biochem Sci. Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. On high-frequency insulin oscillations.
Ageing Res Rev. The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. Maechler P, Wollheim CB. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.
Biochem Soc Trans. Sener A, Malaisse WJ. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase. A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine. Glucagon-like peptide 2, a neurotransmitter with a newly discovered role in the regulation of food ingestion.
Ugeskr Laeger. The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. McGarry JD. Banting lecture dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.
Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Stimulation of insulin secretion by infusion of free fatty acids.
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR Prentki M.
New insights into pancreatic beta-cell metabolic signaling in insulin secretion. Eur J Endocrinol. Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. Gonzalo S, Linder ME. SNAP palmitoylation and plasma membrane targeting require a functional secretory pathway. Mol Biol Cell. Prentki M, Matschinsky FM. Physiol Rev.
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release.
Am J Physiol Endocrinol Metab. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca v 1. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion. Am J Physiol Cell Physiol. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
Pflugers Arch. Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion. Munc is required for the sustained release of insulin from pancreatic beta cells. Munc deficiency reduces insulin secretion and causes abnormal glucose tolerance. Gerst JE. SNARE regulators: matchmakers and matchbreakers. Tomosyn-1 is involved in a post-docking event required for pancreatic beta-cell exocytosis. J Cell Sci. Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner.
Synaptotagmins bind calcium to release insulin. J Gen Physiol. Piccolo complex in cAMP-dependent exocytosis. Catterall WA. Cell Calcium. Annu Rev Cell Dev Biol. Dolphin AC. L-type calcium channel modulation. Adv Second Messenger Phosphoprotein Res. Trends Neurosci. Jpn J Pharmacol. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Triggle DJ. The physiological and pharmacological significance of cardiovascular T-type, voltage-gated calcium channels.
Am J Hypertens. Eur J Biochem. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.
J Physiol. Rorsman P, Trube G. Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells. Henquin JC. The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic B-cells.
Arch Int Physiol Biochim. The role of cyclic AMP in insulin release. The role of cyclic AMP in the control of carbohydrate metabolism. Drucker DJ. Minireview: the glucagon-like peptides. Gastric inhibitory polypeptide: the neglected incretin revisited. Regul Pept. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr Rev. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells.
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. A family of cAMP-binding proteins that directly activate Rap1. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Temporal and spatial coordination of exocytosis and endocytosis. Nat Rev Mol Cell Biol. Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I. Stark JM, Jasin M. Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A. Cell physiology of cAMP sensor Epac. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta.
Sutter-Dub MT. Rapid non-genomic and genomic responses to progestogens, estrogens, and glucocorticoids in the endocrine pancreatic B cell, the adipocyte and other cell types. Rapid insulinotropic effect of 17beta-estradiol via a plasma membrane receptor. Hormone replacement therapy and the cardiovascular system. Nonlipid effects. Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM. A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas.
Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts. Non-genomic actions of 17beta-oestradiol in mouse pancreatic beta-cells are mediated by a cGMP-dependent protein kinase. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB.
Arendt J. Melatonin and the mammalian pineal gland. Chapman and Hall; London: J Pineal Res. Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling. Function and expression of melatonin receptors on human pancreatic islets.
Peschke E. Melatonin, endocrine pancreas and diabetes. Melatonin inhibition of insulin secretion in the rat and mouse. Horm Res. Insulin release from isolated mouse islets in vitro: no effect of physiological levels of melatonin or arginine vasotocin. Parallel signaling pathways of melatonin in the pancreatic beta-cell.
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Influence of melatonin and serotonin on glucose-stimulated insulin release from perifused rat pancreatic islets in vitro. Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets. Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Mammalian melatonin receptors: molecular biology and signal transduction. Cell Tissue Res. Biochem Pharmacol. Godson C, Reppert SM. The Mel1a melatonin receptor is coupled to parallel signal transduction pathways.
Orskov C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide 7—36 amide infused at near-physiological insulinotropic hormone and glucose concentrations. JClin Endocrinol Metab. Ahren B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Mechanisms of action of glucagon-like peptide 1 in the pancreas.
Pharmacol Ther. Positional cloning of the mouse obese gene and its human homologue. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Leptin: a potent inhibitor of insulin secretion.
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Leptin suppresses basal insulin secretion from rat pancreatic islets. Effects of leptin on insulin secretion from isolated rat pancreatic islets.
Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Leptin inhibition of insulin secretion from isolated human islets. Acta Diabetol. Effects of acute or prolonged exposure to human leptin on isolated human islet function.
Interaction of GLP-I and leptin at rat pancreatic B-cells: effects on insulin secretion and signal transduction. Horm Metab Res. Ahren B, Havel PJ. Sonksen PH. Insulin, growth hormone and sport. Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.
Direct effect of insulin and insulin-like growth factor-I on the secretory activity of rat pancreatic beta cells. Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions.
Mol Cell Proteomics. Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol. Tisch R, Wang B. Dysrulation of T cell peripheral tolerance in type 1 diabetes. Adv Immunol. Cytokines as immune effector molecules in autoimmune endocrine diseases with special reference to insulin-dependent diabetes mellitus.
Cytokines as mediators of autoimmune diabetes and diabetic complications. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production.
Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1.
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. Stoffers DA.
The development of beta-cell mass: recent progress and potential role of GLP Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab.
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis. Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.
Ann N Y Acad Sci. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. The role for endoplasmic reticulum stress in diabetes mellitus. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway.
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway.
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications.
Beta-cell adaptation and decompensation during the progression of diabetes. Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity? Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection.
High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB. Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?
Grill V, Bjorklund A. Overstimulation and beta-cell function. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.
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